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End Stages Of Lyme Disease

5 min read

End Stages Of Lyme Disease – It has been found that anywhere from 10-30% of patients treated for primary Lyme disease are left with persistent symptoms, sometimes for months or years. Those diagnosed later have more persistent symptoms.

There are many ways to sustainability. These factors include delayed treatment, chronic disease, co-infection, reactivated infection, genetics, autoimmune and physical damage to the body caused by the disease. Regardless of the cause, these common symptoms share one thing in common – antibiotic resistance.

End Stages Of Lyme Disease

A new paper by Heather Adkinson and Monica Embers of Tulane University dives into three well-known failure practices. It’s called Lyme disease and the search for a cure, published in Frontiers in Medicine.

Stages Of Lyme Disease

The term autoimmunity describes a condition in which the body’s immune system malfunctions. Instead of protecting us from foreign germs, they attack our own bodies and tissues. Common autoimmune-related conditions include type 1 diabetes, lupus, and rheumatoid arthritis.

Lyme arthritis occurs when the immune system attacks the tissue in our joints. Some call this auto-inflammatory process autoimmunity.

Research has shown that patients with persistent symptoms after treatment for Lyme disease have higher levels of antibodies against proteins found in the nervous system – something known to occur in patients with multiple sclerosis. These findings support the hypothesis of an autoimmune component in chronic neurological Lyme disease.

The Borrelia burgdorferi spirochete itself does not directly infect human or animal tissues. But the signs and symptoms of Lyme disease in humans are the result of the immune system’s response to the bacteria.

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The innate immune system – the one we are born with – is the body’s first line of defense against pathogens and harmful substances. In practice, it is immediately issued, but non-specific, to all foreign invaders.

In contrast, the adaptive immune system is more sensitive. It depends on previous knowledge to study and produce specific antibodies. It remembers previous encounters and develops special weapons (B-cells and T-cells) to fight each pathogen.

The adaptive immune system makes copies of these weapons to work faster and better. This part of the immune system is constantly changing our presentation and getting stronger with each session.

Unfortunately, even with a healthy health system, we can get Lyme disease and other tick-borne diseases, often. So each of us is sick. When Borrelia burgdorferi infects the human body, there is a complex interaction between pro-inflammatory and anti-inflammatory elements in the immune system.

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Ideally, with early treatment, our body can eliminate all parts of the bacteria. However, if infection or residual bacteria are left untreated, this can create a cascade of pro-inflammatory chemokines and cytokines. These inflammatory factors can damage our tissues causing various symptoms that affect some or all body tissues such as skin, joints, heart, stomach, brain and others.

Mast cells are the oldest and most primitive part of the immune system. I have written extensively about what happens when mast cells become damaged leading to mast cell activation syndrome—something that is very common in patients with Lyme disease.

The authors also mention several studies where “gamma interferon (IFN-ɣ) was found to be the main factor in the inflammatory pathology seen in the early stages of LD, especially in groups and the nervous system.” It highlights the benefits of monitoring inflammatory markers and taking steps to reduce inflammation during and after treatment for Lyme disease. For example, running a cytokine panel while doing blood work, sticking to a low-carb diet, taking prescription NSAIDS or other ways to reduce Herxheimer’s reactions with many natural remedies to reduce inflammation.

The Johns Hopkins University SLICE study also found several markers that predict patients will develop post-treatment Lyme disease (PTLDS). improvement after standard treatment for Lyme disease.

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Borrelia spirochetes have developed a very clever trick that allows them to evade the immune system and survive for years in animals or humans. If left untreated, Borrelia creates a chronic and persistent infection – this fact cannot be disputed.

Controversy exists over whether Borrelia infection can persist after treatment with antibiotics and whether its persistence is the cause of PTLDS symptoms.

Dr. Ying Zhang, from Johns Hopkins University, has done extensive research on antibiotic resistance. It simulates grass webs continuously growing in a field of grass. Medicines, such as leaf cutters, suppress the growth form of the spirochete but not the persistent form, such as dandelion root. Later, like weeds, the bacteria will grow back.

The problem with these persistent Borrelia cells is that they are not easily cultured in the laboratory—a laboratory technique used to show whether an infection is present in a patient’s blood sample.

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Without confirmation of live bacteria in culture, it is difficult to confirm the cause of persistent symptoms. However, we know that non-viable Borrelia residues can cause an inflammatory reaction.

Another difficult factor is the delay in diagnosis and treatment. Studies have shown that many patients who receive antibiotics within four weeks of the first infection have better outcomes.

Unfortunately, many diseases do not receive treatment in the first window of time. In the MyLymeData study, only 7% of infections were diagnosed in the first month. Nearly 80% reported that it took more than six months to receive an accurate diagnosis.

Delay in diagnosis is due to the unreliability of the standard Lyme test, which measures antibodies to Lyme, not the disease itself. Because the human body takes four to six weeks to develop detectable antibodies, the test results in many false positives. Therefore, the initial diagnosis of Lyme disease is based on symptoms, physical findings (eg, rash), and susceptibility to infection.

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As the authors point out, late diagnosis of Lyme leads to later disease, which is more difficult to treat. Also, the standard treatment for Lyme disease uses doxycycline—a bacteriostatic antibiotic.

Bacteriostatic antibiotics simply inhibit the bacteria’s ability to grow, relying on the immune system to kill and remove the bacteria. If someone is safe, able to fight co-infections, their immune system has a harder time clearing the infection.

As mentioned above, there can be many reasons for persistent symptoms after treatment for Lyme disease. One thing is common: the standard treatment for Lyme disease has killed many patients every year.

Using CDC estimates, we estimate that there are 476,000 new cases of Lyme disease each year. If the disease remains 20%, it leaves approximately 100,000 patients per year with symptoms after standard treatment. This requires further study, new clinical trials, and better treatment options.

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Treatment options to eradicate the infection may include antibiotics used alone or in combination with other medications or essential oils. Drugs to consider include disulfiram, vancomycin, hygromycin A, daptomycin, artemisinin, cefoperazone, azlocillin, cefotaxime and others.

Because a good portion of the initial and ongoing symptoms of Lyme are caused by the immune response, other options for treatment may include immune-modulating drugs. Although there are several monoclonal antibodies approved for the treatment of bacterial infections, none are currently approved for the treatment of PTLDS.

Recently, I saw something that I only dreamed of – scientists, researchers, and representatives of patients from various diseases related to diseases gathered in one room. .

In June 2023, the National Academies of Sciences, Engineering, and Medicine (NASEM) held a two-day event in Washington DC called Towards a Common Research Agenda in Chronic Infection-Related Diseases: A Workshop to Examine Common, Overlapping Clinical and Biological Factors . .

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In the end, I think those of us who look at the evidence come away with a sense of confidence about the disease being reported and a greater awareness of what it’s like to have a long-term illness. I heard from several participants who look forward to the relationships built through NASEM continuing into the future. (See also: “Important Words”: New Ways of Thinking About Chronic Illness.)

Like the author of this paper and the people at NASEM, I hope with the progress of personal medicine, and collaboration with other fields that allow scientific progress, that we find a cure for Lyme disease, which works against Lyme disease and other diseases. it’s a thing of the past.

LymeSci is written by Lonnie Marcum, a licensed Medical Doctor and mother of a daughter with Lyme. He served two terms on a subcommittee of the Federal Tick-Borne Disease Working Group. Follow him on Twitter: @LonnieRhea  Email him at: lmarcum@.

Adkison H, Embers ME. Lyme disease and finding a cure. Front Med (Lausanne). 2023 May 24;10:1183344. doi: 10.3389/fmed.2023.1183344. PMID: 37293310; PMCID: PMC10244525. The latest scientific research has shown that 90% of all cells in the body are microbes. Another way of saying that is 20 times more “bug”

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