Does Ibuprofen Affect Your Liver – According to a new study from the University of California, Davis, ibuprofen can increase liver enzymes. The study, conducted on laboratory mice and published in Scientific Reports, shows significant differences between males and females.
Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs, widely used in medicine to treat pain and fever. Ibuprofen is known to cause heart problems and increase the risk of stroke, but its effects on the liver are poorly understood, says Aldrin Gomez, a professor in the Department of Neurobiology, Physiology and Behavior at UC Davis’ College of Biological Sciences.
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Does Ibuprofen Affect Your Liver
Ibuprofen, a common pain reliever, has been found to be unsafe for women with mild urinary tract infections because it increases the risk of developing a serious upper urinary tract infection.
Gomes, postdoctoral researcher Suchita Tiwari and colleagues gave mice a moderate dose of ibuprofen for a week—the equivalent of an adult taking about 400 milligrams of the drug each day. They then used advanced mass spectrometry at the UC Davis Proteomics Core Facility to capture information about all metabolic pathways in liver cells.
“We found that ibuprofen caused more changes in protein expression in the liver than we expected,” Gomez said.
At least 34 different metabolic pathways were altered in mice treated with ibuprofen. These include pathways involved in the metabolism of amino acids, hormones and vitamins, as well as the production of reactive oxygen and hydrogen peroxide in cells. Hydrogen peroxide damages proteins and irritates liver cells.
The researchers found that ibuprofen had different, and in some cases opposite, effects on the livers of male and female rats. For example, the proteasome—the waste disposal system that removes unnecessary proteins—reacts differently in men and women. Ibuprofen increased the activity of cytochrome P450, which breaks down the drug, in women but decreased it in men.
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“The increase in cytochrome P450 means that other drugs taken with ibuprofen can stay in the body for longer in men and this has not been seen before. No drug is perfect because all drugs have side effects. However, many of them are widely used. ibuprofen Existing drugs are overused and should not be used for some conditions such as mild pain, Gomez said.
In the long term, he said, it is important that the scientific community begins to address the differences between men and women in terms of drug metabolism and effects.
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Please use the information carefully. If you are not a physician, be sure to consult your healthcare provider as this information is not a substitute for professional advice. When you hear the word “overdose,” images of hard drugs or prescription drugs come to mind. And chances are you’ve never thought about overdosing on ibuprofen, but not only that overdosing on this relatively simple pain reliever can put your health at risk.
As the most commonly used over-the-counter pain medication, ibuprofen is used by millions of people every day to reduce symptoms such as headaches, fever, chronic bone and joint pain, muscle aches, PMS cramps, and more. Ibuprofen is the active ingredient in many of the most popular pain relievers on the market today, including Advil, Motrin, Nuprin, and Rufen. In 2013, Advil, which contains ibuprofen, reached a sales volume of approximately $490.9 million in the United States alone. (1)
Ibuprofen Side Effects
Ibuprofen is a type of nonsteroidal anti-inflammatory drug (NSAID); In other words, it helps reduce pain and inflammation in the body because it can reduce hormones that cause inflammation. (2) All pain relievers also interfere with the normal functions of the nervous system, changing the way our nerves transmit “pain” when it occurs in certain areas of the body. Taking ibuprofen can be helpful when you’re injured, sick, or recovering from surgery, but unfortunately, many people overuse it, leading to many side effects and even poisoning.
In some cases, a person may experience an overdose of ibuprofen if they take more than the recommended dose. In fact, in one study of 1,326 ibuprofen users, 11 percent exceeded the daily dose limit. (3) In other cases, the problem is not the dosage – it’s because the person has a medical condition that prevents them from taking the active ingredients of the medicine regularly.
When it comes to taking any medication—whether over-the-counter or over-the-counter—you always want to take the lowest dose that helps relieve symptoms. In other words, more is not better, and taking a higher dose can cause side effects that are worse than the pain and swelling you had when you started.
In the case of ibuprofen, an overdose occurs when a person takes too much or their body does not change and eliminate the drug properly. Ibuprofen works by blocking prostaglandins in the body, sometimes called “local hormones” because they affect specific parts of the body rather than the whole thing. One of their jobs is to create inflammation in an attempt to heal from disease or injury. When needed, inflammation can be a good thing to help us get better, but too much in the long term can cause too much damage and lead to ongoing illness and disease. (4)
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Ibuprofen and other NSAIDs inhibit the synthesis of prostaglandins by blocking the cyclooxygenase enzyme. This is a good thing to stop pain and inflammation, but it can be a problem because it stops the normal functions of the blood, heart and intestines. Some people experience irritation of the intestinal lining, decreased blood clotting, changes in blood pressure, and stomach cramps from ibuprofen.
One of the side effects of taking high doses of ibuprofen is that it can affect your digestive system, especially your stomach or intestines. Another worrisome risk is an increased chance of heart attack or stroke, even in people who aren’t at high risk to begin with. This is especially true if you have other health problems, take very high doses, and use the drug for a long time to control your symptoms. (5)
Ibuprofen has previously been linked to infertility problems in women, but ibuprofen has been linked to infertility in men (6), according to a 2018 study. A French and Danish study analyzed 31 athletic white men between the ages of 18 and 35. Participants took either 600 mg of ibuprofen or a placebo twice a day for two weeks. Among the ibuprofen recipients, luteinizing hormone (LH) — the hormone responsible for testosterone production in men — increased significantly, but the ratio of free testosterone to LH decreased significantly 14 days after the recipients took ibuprofen. This result is known as hypogonadism, which is associated with reproductive and physical disorders and is usually found in older men. In addition, mammary tumors from prostate cancer patients and human steroidogenic cells showed suppression of the endocrine system—a system that includes glands responsible for producing and secreting hormones responsible for body growth, metabolism, and sexual development and function—when exposed. of ibuprofen. (7)
Ibuprofen is considered safe for most adults and children over 6 months of age, although exceptions may be made based on the person’s current medical condition. There are many different conditions that can interfere with how the body absorbs and uses ibuprofen – such as heart disease, stomach or intestinal disorders, or problems with blood clotting properly. (9)
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For mostly healthy adults (see exceptions below), up to 800 milligrams of ibuprofen four times a day is considered a safe upper limit.
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