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Does Ibuprofen Affect The Liver

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Does Ibuprofen Affect The Liver – Ibuprofen is a widely used and important drug, but it is known to affect the heart. A new UC Davis study shows that ibuprofen has multiple and unexpected effects on liver metabolism in mice that differ between males and females. (Getty Images)

According to new research from the University of California, Davis, the common pain reliever ibuprofen may have a greater effect on the liver than previously thought. Research on laboratory mice also shows significant differences between males and females.

Does Ibuprofen Affect The Liver

Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs, which are commonly used to treat pain and fever. Ibuprofen has been shown to cause heart problems and increase the risk of stroke, but its effects on the liver are poorly understood, said Aldrin Gomez, a professor in the Department of Neurobiology, Physiology and Behavior at the Davis College of Biological Sciences.

Ibuprofen: What To Know About The Pain Relieving Drug

Gomez, postdoctoral researcher Shuchita Tiwari and colleagues dosed mice for a week with a moderate dose of ibuprofen, equivalent to about 400 mg of the drug per day for an adult. They then used advanced mass spectrometry at the UC Davis Proteomics Core Facility to gain information on all metabolic pathways in liver cells.

“We found that ibuprofen caused more protein expression changes in the liver than we expected,” said Gomez.

At least 34 different metabolic pathways were altered in male mice treated with ibuprofen. They included mechanisms involved in the use of amino acids, hormones and vitamins, as well as the production of reactive oxygen species and hydrogen peroxide within cells. Hydrogen peroxide damages proteins and suppresses liver cells.

The researchers found that ibuprofen had different, and in some cases opposite, effects on the livers of male and female mice. For example, the proteasome—the garbage disposal system that removes unwanted proteins—reacted differently in men and women. Ibuprofen increases the activity of cytochrome P450, which breaks down drugs, in women but decreases it in men.

Ibuprofen Changes Liver Metabolism In Mice

“The elevation of cytochrome P450 may mean that some drugs taken with ibuprofen can stay in men’s bodies for a long time, and this has never been shown before. There is no perfect drug because all drugs have side effects. However, many commonly used drugs, such as ibuprofen, are overused and they should not be used for certain conditions, such as minor pain,” said Gomez.

In the long run, it is important that the scientific community begins to address the differences between men and women in terms of the metabolism and effects of drugs, he said.

Additional authors on the paper are Manish Mishra, Michelle Salemi, Brett Finney and Joan Newens, all at UC Davis. Gomez also holds a faculty position in the Department of Membrane Physiology and Biology at the UC Davis School of Medicine. This work was supported by the National Institutes of Health and the American Heart Association. According to new research from the University of California, Davis, ibuprofen can increase liver enzymes. A study published in Scientific Reports, conducted on laboratory rats, also shows a significant difference between men and women.

Ibuprofen belongs to a group of drugs called nonsteroidal anti-inflammatory drugs, or NSAIDs, which are commonly used to treat pain and fever. Ibuprofen has been shown to cause heart problems and increase the risk of stroke, but its effects on the liver are not well understood, said Aldrin Gomez, a professor in the Department of Neurobiology, Physiology and Behavior at the Davis College of Biological Sciences.

The Truth Behind Prescription Painkillers

Ibuprofen, a common pain reliever, is dangerous for women with mild urinary tract infections because it can increase the risk of serious upper urinary tract infections.

Gomez, postdoctoral researcher Shuchita Tiwari, and colleagues treated mice for a week with moderate doses of ibuprofen, equivalent to an adult taking about 400 mg of the drug daily. They then used advanced mass spectrometry at the UC Davis Proteomics Core Facility to capture information about all metabolic pathways in liver cells.

“We found that ibuprofen caused more protein expression changes in the liver than we expected,” said Gomez.

At least 34 different metabolic pathways were altered in male rats treated with ibuprofen. They included mechanisms involved in the use of amino acids, hormones and vitamins, as well as the production of reactive oxygen species and hydrogen peroxide within cells. Hydrogen peroxide damages proteins and suppresses liver cells.

Will Ibuprofen And Alcohol Kill You?

The researchers found that ibuprofen had different, and in some cases opposite, effects on the livers of male and female rats. For example, the proteasome—the garbage system that removes unwanted proteins—reacted differently in men and women. Ibuprofen increases the activity of cytochrome P450, which breaks down drugs, in women but decreases it in men.

“Elevation of cytochrome P450 may mean that some drugs taken with ibuprofen can stay in the body for a long time in men, and this has not been shown before. There is no perfect drug because all drugs have side effects. However, many are overused. Drugs like ibuprofen are overused and should not it’s used for certain conditions, like mild pain,” Gomez said.

In the long run, it is important that the scientific community begins to address the differences between men and women in terms of the metabolism and effects of drugs, he said.

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Ibuprofen: Dosage, Side Effects & Other Facts

In June, the WHO raised concerns about 7 Indian cough medicines after complaints from several countries about contamination and health problems.

Women using hormonal contraceptives should explore pain relief alternatives to NSAIDs with their health care providers.

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Please use the information wisely. If you are not a physician, please remember to consult your health care provider as this information does not constitute professional advice. You can use ibuprofen to manage pain, but many medications can have side effects on your body. If you have liver disease, you are at increased risk. Although occasional use won’t have much effect, over time, too much ibuprofen can damage your liver, stomach and intestines. Talk to your doctor before starting an ibuprofen regimen.

Take Painkillers Often? Here’s How To Avoid Ibuprofen Overdose

According to the National Institutes of Health, ibuprofen belongs to a class of drugs known as NSAIDs, or non-steroidal anti-inflammatory drugs. NSAIDs work by blocking the production of substances in the body that cause pain, fever, and inflammation. Used in small doses, ibuprofen is an effective pain killer with few health risks.

According to the Centers for Disease Control and Prevention, ibuprofen contributes to inflammation of the liver. Although not as toxic as acetaminophen, too much ibuprofen can cause toxic hepatitis 1. Too much ibuprofen causes an increase in the production of alanine aminotransferase, or ALT, a liver enzyme that is released when liver cells are damaged or die.

The CDC recommends that patients with hepatitis C should not use ibuprofen. Large doses of the drug can stress the liver and increase liver enzyme levels. If you have chronic hepatitis C and use ibuprofen as a pain reliever, see your doctor regularly to monitor your health and check your liver function.

According to the National Institutes of Health, you should not use ibuprofen if you have any type of liver damage because you may be at increased risk of gastrointestinal bleeding. You are at risk of stomach ulcers and stomach pain.

Is It Bad To Take Ibuprofen Every Day?

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Leah Stannard has been writing about women’s health since 2006. He has and is pursuing a Bachelor of Science in Neuroscience.

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