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Does Gout Medicine Affect Kidneys

4 min read

Does Gout Medicine Affect Kidneys – If you’ve ever experienced gout, it’s something you’ll never forget. You describe feeling like your fingers are being injected. It presents as swelling of the feet or joints that can make it difficult to walk. The text of Dr. Thomas Sydenham’s description of a severe case of gout in 1683 is still used today as one of the best descriptions we have.

“The victim has gone to bed and is in good health. Around 2:00 a.m., he was awakened by a sharp pain in his leg. The heel is very rare in the leg or foot. This pain is like walking, but the parts feel like cold water over them. Then cool down with a little heat. The first moderate pain became more severe. After some time this reaches a high level. . . The feeling of the dirty part is very comfortable and pleasant, because the bed and the box cannot support the weight of a person walking in the room. “

Does Gout Medicine Affect Kidneys

A recent study gives hope to chronic kidney disease patients that high cholesterol and gout symptoms can be prevented with treatment.

Medically Approved Gout Treatments

Over the centuries, people with gout have documented a natural history of dealing with this disease without proper treatment. In patients with chronic kidney disease, Complications has low toxicity that limits treatment options for this rare population, who may have gout symptoms.

In 1962, scientists discovered that gout was caused by excessive monosodium urate (MSU) crystals in the tissues. Uric acid (also called urate) is found in the body as a natural form of protein. A normal level is less than 7.0 mg/dL. Most people with chronic kidney disease experience the first attack as kidney function gradually declines due to depletion of fatty acids.

Some patients have urate levels greater than 7.0 mg/dL without symptoms of gout. This is called hyperuricemia. Once the level reaches 9.0 mg/dL, pain in the affected joints; There is a 5% chance of developing gout symptoms such as swelling and redness. cold temperatures Drinking alcohol, along with eating red meat and seafood, is more likely to happen at night, making gout worse. Fortunately, medications like Lasix can also help reduce nausea in patients with kidney failure, which can cause an acute attack. High-dose aspirin can prevent attacks, but high-dose aspirin can worsen gout. A small daily dose of aspirin to prevent heart attacks does not affect the risk of gout.

Diagnosing gout is not straightforward because even in gout patients who have had gout before, there are many other conditions that have many symptoms. The classic symptom is pain without a known injury. It is very common to start with a red and swollen joint. The two most common causes of gout are calcium pyrophosphate (CPP) crystals in the joints (also known as pseudogout) and bacterial infections. In both cases, proper diagnosis and treatment of infected organs, also known as septicemia, is essential in order to prevent permanent organ damage, as well as the risk of infection spreading through the bloodstream, which we call sepsis, and hospitalization. If not treated immediately, even death.

Fight Back Against Gout

The only way to diagnose gout symptoms is to insert a small needle into the area and remove some of the inflamed fluid. Under the microscope, the total number of white blood cells; The presence or absence of urate crystals and a negative bacterial test confirm gout. Unfortunately, the special microscope needed to diagnose gouty cysts is not available in most doctor’s offices, and most patients will not allow a doctor to insert a needle into a painful joint.

Unfortunately, by relying only on clinical and blood related data, some reports misdiagnose the point of infection as gout by up to 5%. A high level of fatty acids in the blood alone is not enough to confirm the diagnosis. In addition, many of the medications used to treat gout can have serious side effects that make a diagnosis appropriate. In summary, rapid and rapid voluntary fluid testing is still the gold standard for the diagnosis of acute gout, even in diagnosed patients. Obtaining consent from a patient with severe pain to inject into a joint is one of the most difficult conversations a patient and doctor can have. There is no other test that can replace this simple method.

Once gout is diagnosed, dietary restrictions that increase the risk of developing gout can be tried in a variety of ways. Seafood and red meat, which are rich in vitamins and proteins, significantly increase the risk of complications. Fortunately, peas, beans, nuts, Purine-rich plant foods, such as mushrooms and spinach, do not increase the risk of developing gout, and while some foods can trigger them, other patients should not eat them. For those with chronic kidney disease; Dietary changes to prevent gout are parallel to dietary changes to prevent heart disease. For some patients, full-fat dairy products also cause problems. But the most important dietary change is to completely avoid alcohol, which has been historically linked to gouty arthritis and acid flares.

Many medications used to treat gout are not effective in chronic kidney disease, especially when creatinine is less than 30 ml/min. The good news for people progressing on dialysis is that almost all gout patients will have complete resolution of their symptoms. However, about 13% of patients opt for a kidney transplant. Gout will occur more frequently in transplant patients treated with Cyclosporin A (CyA). A possible alternative is to switch to Tacrolimus, which significantly reduces the risk of gout and has similar effects to Cyclosporin A. However, most nephrologists will continue to choose cyclosporin A in well-treated patients, rather than treating gout. Fatty acid levels.

What Is Gout And How To Relieve The Pain

Another effective treatment for patients treated with cyclosporin A is the use of the anticoagulant amlodipine to reverse cyclosporin A-induced vasoconstriction, which reduces fatty acid excretion in renal transplant patients. This method not only reduces the risk of hyperuricemia and gout; It may also reduce the nephrotoxicity associated with cyclosporine A.

Many drugs can be used successfully in kidney transplant patients, including colchicine, but at lower doses than in patients with normal kidney function. This medicine can also be used to prevent future attacks if used daily. Corticosteroids, widely used in many anti-rejection protocols, can also be used successfully to treat gout at doses higher than those used for rejection, reaching pre-gout several days later. Motrin Nonsteroidal anti-inflammatory drugs such as Naprosin and Indocin are often used in acute gout attacks, but special care must be taken to avoid the secondary effects of hypertension and elevated potassium levels in kidney transplant patients.

Allopurinol has been used for decades to lower fatty acids by stopping the last step of protein breakdown, greatly reducing the symptoms of gout. However, in kidney transplant patients, Allopurinol also interferes with the metabolism of azathioprine, a drug commonly used to suppress the immune system, which can cause low levels of disease-fighting white blood cells. Most doctors can reduce the level of Azathioprine or substitute Mycophenolate mofetil if Allopurinol is used to prevent gout. However, some nephrologists avoid any changes in order to be effective immunosuppressants and use Colchicine, which reduces the intensity of gout crystals in the joints, to reduce fatty acids in the blood.

Colchicine causes diarrhea in about 80% of patients; There are many side effects, including vomiting and abdominal pain. However, long-term damage to muscles and tendons; Allergic hair loss, skin diseases and dermatitis; Long-term side effects can be very serious, including reduced fertility and kidney failure. The most dangerous thing is to stop the distribution of white blood cells in the blood, which can be fatal.

What Is Gout?

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Celebew A fashion designer...
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